氢氧化铝
Aluminium hydroxide or aluminium hydroxycarbonate, is the most widely used antacid active. It is available as both a suspension and powder and can be used alone or in combination with magnesium hydroxide. 氢氧化铝凝胶在抗酸剂配方中的广泛使用基于其优异的药理学特性，多年的管理中已反复证实这一点。Aluminium hydroxide gel is an effective neutraliser and buffer of gastric hydrochloric acid, with no known harmful side effects. We offer a vast selection of aluminium hydroxide grades with a variety of properties.
Aluminium Hydroxide Powder
Aluminium hydroxide powders are manufactured from suspensions via defined drying processes which result in powders with varying density and particle size characteristics. The powders are primarily used in the production of antacid tablets, preferably after pre-granulation.
ALUGEL® A 211
ALUGEL® A 211 is the most widely used active for tablet, granulate or powder manufacture. Its high reaction capacity with hydrochloric acid ensures rapid onset and prolonged action in the stomach. The typical morphology of this spray dried gel can be seen in fig.1.
ALUGEL® A 215
ALUGEL® A 215 has the fastest reaction rate of all aluminium hydroxide powders, requiring only a few minutes to achieve full reactivity. It is very stable on storage, with physical and chemical properties similar to those of ALUGEL® A 211.
ALUGEL® A 225
ALUGEL® A 225 is an aluminium hydroxide powder with a low bulk density making it the active of choice when formulating with low density additives.
It is particularly suitable for use in candies and soft tablets due to its very fine particle size distribution. The small particles are easily mixed into the gum matrix of these types of products.
ALUGEL® A 225 的精细粒径分布让其成为液体配方中再悬浮的理想选择。
Aluminium Hydroxide Wet Gel
Wet gels are used predominantly in the manufacture of liquid antacid preparations. Their ease of administration, pleasant taste, high active content and rapid onset of action compared to tablets, as well as the availability of practical packaging, e.g. dosed sachets, make liquid preparations a well accepted dosage form for antacids.
ALUGEL® suspensions are produced with a range of solid contents and rheological properties enabling the customers to choose the grade most suitable for their particular requirements.
ALUGEL® A 611
ALUGEL® A 611 is a standard, low viscosity, pumpable paste with an Al(OH)3 content of 14,5 – 16,8%. 它主要用于需要良好流动特性和高活性含量的配方中。The low viscosity allows the incorporation of additional antacid components in powder form.
| Assay | Al(OH)3 = 14,5 - 16,8% Al2O3 = 9,5 - 11,0% |
| Viscosity (Brookfield) | 3000 - 7000 mPa s (LV, 3/12) |
| Pharmacopoeia | USP |
ALUGEL® A 621
ALUGEL® A 621 比 A611 具有更高的反应性和粘度，适用于无需额外活性或粘度调节剂的配方。If required, additional substances may be incorporated after dilution. ALUGEL® A 621 provides remarkably stable suspensions with minimal sedimentation.
| Assay | Al(OH)3 = min. 13,6% Al2O3 = min. 8,9% |
| Viscosity (Brookfield) | 30 - 130 mPa s (LV, 2/60) at 6,1% Al(OH)3 |
| Pharmacopoeia | USP |
ALUGEL®A 651
ALUGEL® A 651 is a highly concentrated gel with an Al(OH)3 content of 19,1 – 20,6%. It has a limited flow capability, but after dilution to approx. 15,3 % Al(OH)3, ALUGEL® A 651 becomes a free flowing suspension with minimum sedimentation characteristics and a rapid reaction rate with hydrochloric acid.
ALUGEL® A 661
ALUGEL® A 661 is the most viscous of the ALUGEL® grades and has an
Al(OH)3 content of more than 13,6%. ALUGEL® A 661 is an outstanding product in terms of reaction velocity and storage stability. 即使稀释到 6,1％ Al(OH)3 的浓度，悬浮液也极为粘稠，具有抗沉积性，不含额外的增稠剂，是稳定悬浮液的首选产品
| Assay | Al(OH)3 =min. 13,6% Al2O3 = min. 8,9% |
| Viscosity (Brookfield) | 500 - 2500 mPa s (LV, 2/12) at 6,1% Al(OH)3 |
| Pharmacopoeia | USP |
ALUGEL® A 671
ALUGEL® A 671 is a free flowing, pumpable, suspension with an Al(OH)3 content of 19,1 – 20,6 %. It is suitable for use in double and triple strength antacid preparations which retain good flow capability. ALUGEL® A 671 displays only slight sedimentation even after extremely long periods in transit or storage. An extremely low sodium grade of ALUGEL® A 671 is available upon request. This special type enables the production of antacids which are classified as sodium-free according to FDA regulations.
| Assay | Al(OH)3= 19,1 - 20,6% Al2O3 = 12,5 - 13,5% |
| Viscosity (Brookfield) | max. 5000 mPa s (LV, 3/12) |
| Pharmacopoeia | USP |
ALUGEL®A 681
With an Al(OH)3 content of 24,5 – 27,5 %, ALUGEL® A 681 is the most highly concentrated aluminium hydroxide suspension available today. Alugel® A 681 是一种可泵送凝胶，钠含量极低，中性气味，可制成口感宜人的产品。As a result of its thixotropic properties, ALUGEL® A 681 displays no signs of sedimentation even after long periods in transit or storage.
| Assay | Al(OH)3 = 24,5 - 27,5% Al2O3 = 16,0 - 18,0% |
| Viscosity (Brookfield) | max. 5000 mPa s (LV, 3/12) |
| Pharmacopoeia | USP |
